Nutrition and Its Influence on Person’s Health: Analysis of Two Articles

Topic: Health Words: 908 Pages: 2 Aug 29, 2022

The main reading (research)

Mohammad‐Shahi, M., Mowla, K., Haidari, F., Zarei, M., & Choghakhori, R. (2016). Soy milk consumption, markers of inflammation and oxidative stress in women with rheumatoid arthritis: A randomised cross‐over clinical trial. Nutrition & Dietetics, 73(2), 139-145.

Additional readings:
- Kelepouri, D., Mavropoulos, A., Bogdanos, D. P., & Sakkas, L. I. (2018). The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis. Journal of Immunology Research, 2018, 1-11. doi:10.1155/2018/93243572018.
- Rezazadegan, M., Mirjalili, F., Clark, C. C., & Rouhani, M. H. (2020). The effect of soya consumption on inflammatory biomarkers: A systematic review and meta-analysis of clinical trials. British Journal of Nutrition, 1-12.
Number of pages read: 30.
Keywords: inflammation, markers of inflammation, rheumatoid arthritis, diet.
Link to the reading: Web.
The reason for selecting the reading: The study of the impact of soy milk diet in women with rheumatoid arthritis is interesting since the nutritional support in the complex treatment of rheumatic diseases can attract attention for its non-drug therapeutic effects.
The main point of the reading: The research studied the effect of soy milk consumption on the markers of inflammation in women with rheumatoid arthritis. The study involved 25 patients with an average age of 45.72 years with rheumatoid arthritis (Mohammad‐Shahi et al., 2016). According to the results obtained, the consumption of soy milk made changes in the percentage of serum hs-CRP and tumor necrosis factor-α (TNF-α) levels. Therefore, the soy milk diet resulted in significant improvements in several inflammatory markers (TNF-α and hs-CRP).
The key takeaway from the readings: Diet can affect the production of prostaglandins and antibodies in a variety of diseases. Therefore, nutritional therapy for rheumatoid arthritis is of great importance (Kelepouri et al., 2018). Of course, anti-inflammatory drugs have a much more active effect on the synthesis of pro-inflammatory enzymes, but the role of soy, that is, flavonoids in a diet can be a reliable and effective means of altering the reactivity of tissues involved in the inflammatory process (Rezazadegan et al., 2020). The analyzed studies show that in a group of patients taking soy milk, inflammatory biomarkers significantly decrease.
Reliability and validity of material: The validity of this study is supported by other current studies that have shown the usefulness of soy milk in comparison with whole cow milk, not only in rheumatoid arthritis but in other inflammatory diseases.

The main reading (research)

Rascon, J., Rageliene, L., Stankeviciene, S., Palionis, D., Tamosiunas, A. E., Valeviciene, N., & Zvirblis, T. (2014). An assessment of iron overload in children treated for cancer and nonmalignant hematologic disorders. European Journal of Pediatrics, 173(9), 1137-1146.

Additional readings:
- Garcia-Casal, M. N., Pasricha, S. R., Martinez, R. X., Lopez-Perez, L., & Pena-Rosas, J. P. (2018). Are current serum and plasma ferritin cut-offs for iron deficiency and overload accurate and reflecting iron status? A systematic review. Archives of Medical Research, 49(6), 405-417.
- Paisant, A., Boulic, A., Bardou-Jacquet, E., Bannier, E., D’assignies, G., Lainé, F.,… & Gandon, Y. (2017). Assessment of liver iron overload by 3 T MRI. Abdominal Radiology, 42(6), 1713-1720.
Number of pages read: 31.
Keywords: iron assessment, anemia, iron overload, markers of inflammation, hematologic disorders.
Link to the reading: Web.
The reason for selecting the reading: I have chosen this reading since today, iron overload syndrome is a common phenomenon that accompanies various diseases and conditions. That is why the assessment of iron status is important to determine the appropriate treatment for iron overload syndrome.
The main point of the reading: The study involved 66 patients under the age of 18 years with secondary iron overload on the background of hematological diseases (Rascon et al., 2014). Assessment of the degree of iron overload of the body and the selection of adequate chelation therapy was one of the important tasks in the management of these patients. The safest, due to non-invasiveness, and quite accurate method was magnetic resonance imaging (MRI) in the T2 * mode, which allowed assessing the accumulation of iron in various organs, primarily in the liver.
The key takeaway from the readings: Iron overload is one of the main reasons that significantly reduce the quality of life of patients with hematological diseases. As several studies have shown, a comprehensive assessment of the accumulation of iron in organs both before the first appointment of chelation therapy and in dynamics allows timely correction of the dose regimen(Garcia-Casal, al., 2018). It preserves the normal function of not only the liver and myocardium but also the endocrine organs. A comprehensive assessment of the accumulation of iron in organs both before the first appointment of chelation therapy and in dynamics allows timely correction of the dose regimen. It preserves the normal function of not only the liver and myocardium but also the endocrine organs (Paisant et al., 2017). Chelation therapy should be started at an iron concentration in the liver of 6-7 mg / g d.v., which corresponds to approximately 170-200 ml / kg of transfused erythrocyte mass (Rascon et al., 2014). If it is not possible to conduct a liver biopsy, or MRI in the T2 * mode, then it is important to focus on the concentration of serum ferritin (Paisant et al., 2017).
Reliability and validity of material: The research can be considered reliable and valid since the study has used data from the existing comparative studies. The System of Classification, Evaluation, Development, and Review of Recommendations (GRADE) was used to assess the reliability of research results, strength of recommendations, and level of evidence.

References

Garcia-Casal, M. N., Pasricha, S. R., Martinez, R. X., Lopez-Perez, L., & Pena-Rosas, J. P. (2018). Are current serum and plasma ferritin cut-offs for iron deficiency and overload accurate and reflecting iron status? A systematic review. Archives of Medical Research, 49(6), 405-417.

Kelepouri, D., Mavropoulos, A., Bogdanos, D. P., & Sakkas, L. I. (2018). The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis. Journal of Immunology Research, 2018, 1-11. doi:10.1155/2018/93243572018

Paisant, A., Boulic, A., Bardou-Jacquet, E., Bannier, E., D’assignies, G., Lainé, F.,… & Gandon, Y. (2017). Assessment of liver iron overload by 3 T MRI. Abdominal Radiology, 42(6), 1713-1720.

Rezazadegan, M., Mirjalili, F., Clark, C. C., & Rouhani, M. H. (2020). The effect of soya consumption on inflammatory biomarkers: A systematic review and meta-analysis of clinical trials. British Journal of Nutrition, 1-12.